In 1996, David Deamer and Daniel Branton’s labs at UC Santa Cruz and Harvard collaborated on a paper showing that when an electric current runs through a nanopore, passing purine (A and G) and pyrimidine (T and C) DNA bases through the nanopore disrupted the current to different degrees. While the technique couldn’t yet discriminate between all four bases, the general idea for a new single-molecule sequencing method was there.
OK—the nightmare is over. Thus concludes my anxiety-ridden spiral. Here are the facts as they stand in 2026:
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Фото: Tom Nicholson / Reuters
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